Depression is one of the most common mental health conditions in Orange County, affecting people of all ages and backgrounds. While traditional antidepressants such as SSRIs and SNRIs have helped millions of people, not everyone finds relief with these medications. If you or a loved one has tried multiple antidepressants without success, you may be exploring alternatives. One option that’s growing in recognition is Spravato® (esketamine) — an innovative treatment available at Anaheim Community Hospital.
In this post, we’ll explain how Spravato differs from standard antidepressants, when it may be a better option, and what Orange County patients should know before starting treatment.
How Traditional Antidepressants Work
Traditional antidepressants, including SSRIs (Selective Serotonin Reuptake Inhibitors) and SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors), target chemical imbalances in the brain. They work by increasing the levels of serotonin, norepinephrine, or dopamine — neurotransmitters that affect mood.
While these medications are often effective, they come with challenges:
- Delayed onset: Relief can take 4–8 weeks.
- Trial-and-error: Some patients may try multiple medications before finding the right one.
- Side effects: Weight changes, fatigue, sexual side effects, and gastrointestinal issues are common.
- Treatment resistance: For some individuals, symptoms remain despite several antidepressant trials.
What Makes Spravato Different
Spravato (esketamine) is a FDA-approved nasal spray for adults with treatment-resistant depression or major depressive disorder with suicidal thoughts or actions. Unlike traditional medications, Spravato works on the NMDA receptor in the brain, creating a unique pathway to relieve depressive symptoms.
Key advantages of Spravato include:
- Rapid effect: Many patients notice improvement within hours to days.
- New mechanism: Targets glutamate, not just serotonin or norepinephrine.
- Administered in a safe setting: Spravato must be given in a certified medical facility like Anaheim Community Hospital, where patients are monitored during each session.
Spravato vs. Traditional Antidepressants
| Feature | Traditional Antidepressants | Spravato (Esketamine) |
|---|---|---|
| Mechanism | Serotonin, norepinephrine, dopamine reuptake | NMDA receptor / glutamate pathway |
| Time to Effect | 4–8 weeks | Hours to days |
| Administration | Oral pills | Nasal spray under supervision |
| Who It Helps | Many with mild to moderate depression | Adults with treatment-resistant depression or suicidal ideation |
| Setting | Home use | In-clinic, monitored |
Who Is a Candidate for Spravato?
You may be a candidate for Spravato if:
- You have tried two or more antidepressants without success.
- You experience major depressive disorder with suicidal thoughts.
- You are under the care of a psychiatrist or mental health provider who recommends Spravato.
At Anaheim Community Hospital, patients undergo a comprehensive evaluation to determine eligibility. Our team works with you to ensure Spravato is a safe and appropriate treatment.
Insurance & Access in Orange County
One of the most common questions we hear is: “Does insurance cover Spravato?”
The good news is that many insurance providers now cover Spravato treatment when medically necessary. Our staff helps patients navigate insurance approvals and financial questions so cost doesn’t become a barrier to care.
Which Treatment Is Right for You?
Traditional antidepressants remain a first-line treatment for many people with depression. However, for those living with treatment-resistant depression, Spravato may offer new hope for recovery.
If you’re wondering whether Spravato is right for you, the best next step is to speak with a qualified provider. Anaheim Community Hospital is proud to be one of the few certified facilities in Orange County offering this advanced therapy.
Take the Next Step Toward Healing
At Anaheim Community Hospital, we understand how frustrating it can be to try medication after medication without relief. That’s why our Spravato program is designed to give patients in Anaheim and surrounding Orange County communities access to a safe, effective, and innovative treatment option.
📞 Call us today at 714-243-9090 to schedule a consultation.
Or visit our Spravato Treatment Clinic page to learn more.